University of Wisconsin School of Medicine and Public Health
Research Interests Keywords: Retinal tissue engineering, Stem cells and retinal organoids, Neuron transplantation, Microphysiological systems, Neural plasticity Our research focuses on developing regenerative therapies to restore vision after injury and disease. We use human stem cell-derived models, tissue engineering, electrophysiology, and neuroengineering to study how retinal ganglion cells develop, form functional connections with the brain, …
Biography Research Interests Molecular and cellular mechanisms of human brain development and evolution. The development of the human brain is a long and complex process that is precisely choreographed through tightly regulated transcriptional programs. Proper regulation of these programs is necessary for developing the numerous functionally distinct regions and cell types of the brain. Since …
Biography Research Interests The South lab studies mechanisms of squamous cell carcinoma (SCC) initiation and progression with a view to developing preventative or curative intervention. One approach to achieving this goal is to study rare familial tumor prone disorders that can inform on more common cancer. We currently focus on aggressive SCC occurring in patients …
Lab Website Sridharan Lab Biography Research Interests The main scientific focus of the lab is in defining how the epigenome controls cell fate. During the development of a multicellular organism a single cell can give rise to an entire organism made of a multitude of cells of specialized function. Such functional specification is determined both by the …
Lab Website Suzuki Lab Biography Research Interest Kinetochore/Centromere Integrity and Cancer The Suzuki laboratory focuses on elucidating the molecular mechanisms underlying kinetochore functions in cell division. The kinetochore is a macro-molecular protein complex on centromeric chromatin, and it ensures the integrity of chromosome segregation. Kinetochore dysfunction causes chromosomal instability, which leads to carcinogenesis and developmental …
Lab Website The Svaren Lab Biography Research Interests Our laboratory is devoted to research on transcriptional and epigenomic regulation of myelination and pathogenesis/treatment of peripheral neuropathies. I have a long standing interest in the interplay of chromatin structure and gene regulation, and we were the first to develop chromatin immunoprecipitation analysis to identify regulatory elements …
Lab Website Tang Lab Biography Research Interests We are interested in developing novel molecules for treating human diseases and facilitating the study of cell biology. Our research covers many aspects of pharmacology. We are particularly interested in developing novel molecules that can selectively degrade disease-causing proteins, which include a wide range of oncogenic proteins and …
Lab Website Tibbetts Lab Biography Research Interests Research projects in our lab broadly pertain to genomic surveillance and molecular mechanisms of neurodegeneration in ALS. Current areas of focus include: (i) Non-canonical regulation of CREB/ATF transcription factors: relevance to tumor suppression and metabolic homeostasis. Mutations in the ATM protein kinase cause ataxia-telangiectasia (A-T), a syndrome of …
Research Interests Our research is driven by a fundamental question: what defines G0? Nearly every cell exits the cell cycle either as a quiescent, stem-like cell poised for activation or as a terminally differentiated cell with specialized function, yet the signaling mechanisms that govern cell cycle exit and fate commitment (and whether a universal G0 …
Biography Research interest The long-term goal of my research program is to develop new therapeutic strategies using mechanistic insights drawn from understanding astrocyte-motor neuron interaction in amyotrophic lateral sclerosis (ALS). While the degeneration of motor neurons is the characteristic feature of ALS, astrocytes play a key role determining motor neuron fate in the course of …