University of Wisconsin School of Medicine and Public Health
Biography Research Interests Defining mechanisms by which diet and xenobiotics impact host-microbiota-immune dialogues with consequences for autoimmunity. Our lab is investigating the impact of diet and xenobiotics on microbiota-immune crosstalk. In previous collaborative studies, we investigated how a common drug used in treatment of autoimmune patients (methotrexate) perturbs the gut microbiome and reduces immune activation …
Biography Research Interests The long-term goal of the Alvarado Lab is to is to understand the mechanisms of heart disease and to develop safe and effective treatments that improve the life of patients. Our primary interest is the regulation of cardiac ion channels with emphasis on diseases arising from their dysfunction, especially calcium-dependent arrhythmias and …
Lab Website Anderson Lab Biography Research Interests Cell Signaling from Receptor to the Nucleus; Systems Biology; Cancer Biology The goals of the Anderson lab’s research are to understand the biological roles of cell signaling and the underlying mechanisms by which receptors, cell stresses and second messengers modulate specific cellular processes. The research is currently focused …
Lab Website Audhya Lab Biography Research Interests Our laboratory is committed to understanding the fundamental mechanisms by which membrane proteins, lipids, and other macromolecules are transported throughout eukaryotic cells. To do so, we take advantage of numerous interdisciplinary approaches, including pharmacology, biochemistry, structural biology, biophysics, genetics, molecular biology and high-resolution fluorescence and electron microscopy. Additionally, …
Biography Research Interest We study the neuropharmacology of mental illness using rodent models of the discrete behavioral deficits seen it schizophrenia, PTSD, depression, and anxiety. Our goal is to identify novel neural substrates that can be targeted for future drug development efforts to treat these illnesses. We utilize a systems neuroscience approach incorporating techniques ranging …
Lab Website mmb Lab Biography Research Interest Basic cell culture techniques have changed little in almost a century. By far the most dominate format for cell culture is the Petri dish or similar (e.g. multi well plate). Slowly this is beginning to change as our ability to create materials, geometries and even systems at the …
Lab Website Bement Lab Biography Research Interest Our lab has a long-standing interest in the means by which the cytoskeleton controls cell division, wound healing, and endocytosis. We have developed several model systems that help simplify analysis of complex, cytoskeleton-dependent processes; these are described in our recent publications. Honors & Awards Kellett Mid-Career Award, Wisconsin …
Biography Research Interests Our lab is committed to understand the mechanisms of impairment and failure of biological systems under pathological conditions, focusing on tissue stem cells, vasculature and the peripheral nervous system present in different tissues microenvironments, with emphasis on preventing or reversing these deleterious processes. We are interested in studying mechanisms that lead to cell …
Biography Research Interests Regulation of terminal differentiation and functional maturation of stem and progenitor cells, regenerative biology of the endocrine pancreas, diabetes How does a newly formed stem or progenitor cell “know” it had reached its full differentiation capacity, and should assume its mature function? What part of the signal towards terminal differentiation comes from …
Biography Research Interests Hematopoiesis, Blood Cancer Mechanisms and Genome/Epigenome Function The Bresnick group conducts basic and translational research on genomics/epigenomics, hematopoiesis, myeloid/erythroid cell biology and pharmacology. We discovered GATA2 enhancers that are essential for hematopoiesis and embryonic development, and their disruption causes human diseases. Our studies unveiled paradigms to explain hematopoietic stem cell generation, progenitor …