People Type: Faculty

Biography Research Interests The major focus of the lab is on understanding the function and structure of the GABA-A receptor. GABA-A receptors are the major inhibitory neurotransmitter gated-ion-channels in the brain. While GABA controls the opening of the anion-conducting channel, GABA-A receptor function is modulated by a variety of clinically important classes of drugs, including …

Lab Website Davis Lab Biography Research Interests Dr. Davis runs a federally funded research lab focused on pancreatic beta cell biology.  One area of focus is on understanding the mechanisms underlying the growth response in the beta cell.  Beta cells normally do not grow, but can be stimulated to divide and expand in response to …

Research Interests Dr. Deming’s research program focuses on developing treatments for subtypes of colon cancer and other gastrointestinal cancers using animal models to test personalized regimens for patients based on each patient’s tumor mutations. His laboratory has developed 3-dimensional cell culture techniques for clinical cancer research. He also leads work to identify new and improved …

Research Interests My research in pharmacology focuses on identifying and therapeutically exploiting mechanisms of epigenetic plasticity and lineage state transitions in sarcomas, which are aggressive connective tissue cancers. My work integrates single-cell and spatial multiomic technologies, functional genomics, and translational oncology to define how alterations in chromatin regulation drive aggressive cancer phenotypes and therapeutic resistance. …

Lab Website Denu Lab Biography Research Interests The laboratory investigates the mechanism and biological function of reversible protein modifications involved in modulating signal transduction, chromatin dynamics and gene activation. Histones are one of the best examples of protein function regulated by modification, and are the target of an array of modifications including acetylation, phosphorylation and …

Biography Research Interest Cancer is a heterogeneous disease that complicates its study and, therefore, treatment. Immunotherapy has revolutionized cancer treatment, but many patients still are faced with little or no clinical benefit with the same treatment. Recent high-dimensional technologies have allowed us the ability to understand the tumor ecosystem and its impact on treatment response. …

Research Interests My research focuses on how metabolic pathways regulate neuronal survival and function in eye diseases The Du Laboratory integrates metabolomics, molecular biology, and disease models to investigate how alterations in glucose, lipid, and amino acid metabolism contribute to retinal degeneration to fight blindness. A major goal of our work is to identify metabolic …

Biography Research Interests Research work in my lab and my clinical practice focuses on the study and treatment of inherited arrhythmia syndromes. My particular interest is in potassium inward rectifiers (Kir2), which is the dominant component of IK1, and their contribution to cardiac sudden death, both from inherited and acquired arrhythmia syndromes. We use human …

Lab Website Fan Lab Biography Research Interests Mammalian cellular metabolism is a dynamic process that consists of thousands of interconnected reactions and regulatory interactions. While the architecture of metabolic networks is defined by the genome, actual metabolic activity (i.e. metabolic flux) through the pathways varies greatly. Dynamic reprogramming of metabolism enables cells to meet metabolic …