University of Wisconsin School of Medicine and Public Health
Biography Research Interests Keywords: Synthetic pharmacology; protein engineering; chemical biology; drug discovery; GPCRs The Kalogriopoulos Lab, located in the University of Wisconsin–Madison School of Pharmacy, operates at the interface of protein engineering, synthetic biology, chemical biology, and pharmacology. Our core mission is the rational design of molecular tools to achieve unprecedented control over complex cellular …
Biography Research Interests Cardiovascular Calcium Channels Function, Structure and Regulation. Cardiac Ca2+ channels play an important role in cellular excitability by allowing the rapid influx of Ca which depolarizes the cell. The resulting increase in intracellular [Ca2+] is essential for regulation of Ca2+-dependent processes including excitation-contraction coupling, excitation- secretion coupling, and gene regulation. Current research …
Biography Research Interests The capacity for complex tissue regeneration is unevenly distributed across species. Unlike human, zebrafish possess a remarkable potential to regenerate tissues such as amputated appendages and damaged heart muscles. Interest of my laboratory is to understand how and what genetic and epigenetic factors control tissue regeneration using adult zebrafish as a model …
Lab Website Kimple Lab Biography Research Interests View full description here. In the Kimple Lab we seek to improve the care of cancer patients through our strengths in translational radiation research while providing a supportive world-class learning environment for scientists at all levels. Honors & Awards 2010-2012 – Kaye Fellow in Head and Neck Cancer Research …
Lab Website Kimple Lab Biography Research Description Research in the Michelle Kimple lab is focused on how the endocrine cells of the pancreatic islet of Langerhans coordinate to regulate hormone secretion in response to glucose and other stimuli; impacting whole-body fuel metabolism. The Kimple Lab is especially interested in elucidating how G protein signaling networks …
Biography Research Interests The Kosoff Lab is focused on developing new therapeutic strategies for cancer treatment. Our primary research interest is the tumor microenvironment (TME), which is the array of non-malignant cells (immune cells, stromal cells, etc.) and stroma that support cancer progression and the development of therapeutic resistance. Our research is aimed at identifying …
Biography Research Description Gastrointestinal cancers represent complex diversity at baseline yet tracking diversity to resistance remains a formidable barrier to effective targeting strategies. Our laboratory utilizes patient-derived organoid cultures to characterize the diversity of hepatobiliary and pancreatic cancers in response to therapeutic challenge. We map the molecular heterogeneity under selection of therapeutic pressure and characterize …
Lab Website Kreeger Lab Biography Research Interests Cellular and Signaling Network Cross-Talk in Ovarian Cancer Ovarian cancer has a mortality rate of greater than 50%, primarily due to the late stage at which it is diagnosed. This late diagnosis complicates treatment – patients accumulate different mutations in their tumors and tumor cells receive a variety …
Lab Website Lamming Lab Biography Research Interests Our laboratory is focused on understanding how what, when, and how much we eat can regulate metabolic health and aging. We discovered that low protein diets promote metabolic health and lifespan – improving blood sugar control and reducing adiposity – in humans and mice, and we have identified …
Biography Research Interests Single-domain antibody engineering Targeted radionuclide therapy and nuclear imaging Antibody-drug conjugates Strucutral biology The LeBeau laboratory operates at the interface of synthetic biology and nuclear medicine. Our goal is to decrease cancer mortality and morbidity by developing antibody‑based molecular imaging agents and targeted therapeutics. We are pioneering the use of Variable New …