University of Wisconsin School of Medicine and Public Health
Biography Research Interests The Leone lab studies host-microbe interactions using preclinical models, including germ-free mouse technology. Dr. Leone currently holds a National Institutes of Health Diabetes and Digestive and Kidney Diseases K01 Mentored Research Scientist Career Development Award, focusing on determining the mechanism of how diet-induced gut microbes shape and maintain host circadian clock function …
Biography Research Interest My research program is rooted in the idea that eukaryotic chromatin, the physiologically relevant form of genomes, contains an indexing system that represents a fundamental regulatory mechanism. Covalent modifications to both DNA and histone proteins allow chromatin to act as a dynamic information hub that integrates diverse biochemical stimuli to regulate genomic …
Lab Website Li Research Group Biography Research Interests Neuropeptides are an important class of signaling molecules and can act as drugs. Currently relatively little is known about neuropeptides and the technology available today is not sufficient to address many of the challenges. This is a promising area that needs both new technologies and creative insight …
Biography Research Interests Genome-wide association studies provide increasing evidence of linkage between common genetic variants and complex disease susceptibility. One of the most challenging problems in studying human disease biology is the influence of mutations in non-coding regions. Yet, these are the most common regions identified with genome association studies. Although the number of genetic variants linked …
Biography Research Description Project 1: How do DNA viruses localize to cellular sites of DNA damage? We are interested in understanding how viruses localize to distinct cellular sites within the host cell’s nucleus. We have adapted high throughput chromosome conformation capture-based methods to map the sites in host cells where the viral genome can localize. …
Lab Website Daniel Matson Laboratory Biography Research Interest Disorders of the blood and bone marrow are of great public health significance. During development and in the adult bone marrow, a relatively small number of critical transcription factors promote complex and diverse cellular processes to bring about faithful and timely hematopoiesis. The mechanisms by which these …
Biography Research Interests Cells must sense and process diverse stimuli in order to survive and thrive. The McClean research group takes a bioengineering approach to answering fundamental and medical questions about biological signal processing with an emphasis on model and pathogenic yeasts. Publications https://scholar.google.com/citations?user=fbdn9KsAAAAJ
Biography Research Interests We study JAK inhibitors in Sjogren’s Disease. Our past work focused on the effect of a specific JAK 1/2 inhibitor on fibroblasts cultured in vitro. Our submitted work focuses on the the effect of JAK inhibitor withdrawal on STAT signaling in disease. In the future, we are expanding our understanding of interferon …
Lab Website Moore Lab Biography Research Interests My lab is interested in the question of how and why somatic stem cells dysfunction with age. Throughout life, stem cells are responsible for replenishing and regenerating tissue, fundamentally maintaining “youthfulness.” With aging, this ability is lost, resulting in effects such as cognitive impairment, reduced immune response, deterioration …
Lab Website Murphy Group Biography Research Interests Bioinspired, Non-Covalent Assembly of Materials: Stem cell activities, including self-renewal and differentiation, are strongly influenced by signals present in their microenvironment. Our group is using novel materials chemistry to control the signals present in the local stem cell microenvironment. Our approaches use non-covalent interactions between biological molecules (e.g. …